G蛋白偶联受体在T淋巴细胞免疫调节作用中的研究进展

Research progress on the role of G-protein-coupled receptors in T lymphocyte immunomodulation

摘要:

G蛋白偶联受体(GPCRs)是一类跨膜受体超家族,参与多种信号转导通路,在细胞迁移、代谢等生理过程中发挥重要功能。T淋巴细胞是重要的免疫细胞,参与炎症反应过程并在细胞免疫中发挥重要作用。目前已发现多种GPCRs在T淋巴细胞中表达并参与T淋巴细胞免疫调节过程,本文将对GPCRs在T淋巴细胞免疫调节中的作用进行综述。

Abstract:

G-protein-coupled receptors (GPCRs) are a type of superfamily of transmembrane receptors, involved in multiple signaling pathways, and playing an important role in physiological processes such as cell migration and metabolism. T lymphocytes are important immune cells that participate in the inflammatory process and play an important role cellular immunity. To date, multiple GPCRs have been found to be expressed in T lymphocytes and participate in T cell immunomodulatory processes. This paper reviews the role of GPCRs in T lymphocyte immunomodulation.