某医院1999—2008年临床分离细菌种群分布与变迁 FREE

Distribution and change of microbial population of clinical isolated bacteria from a hospital between 1999 and 2008 FREE

摘要:

目的了解某院近10年来临床分离细菌的菌群分布和变迁情况。方法对该院1999年1月—2008年12月间住院和门诊就诊患者送检的60 846份临床标本（血液、尿液、咽拭子、痰、大便、阴道拭子和无菌体液）细菌培养结果作回顾性分析。结果10年共分离临床细菌67属207种18 674株，细菌分离率30.69%(18 674/60 846)，革兰阴性杆菌、革兰阳性球菌与真菌的比例为54.42∶32.21∶11.56。前6位优势菌群分别是甲型副伤寒沙门菌、草绿色链球菌群、大肠埃希菌、酵母样真菌、凝固酶阴性葡萄球菌和金黄色葡萄球菌。革兰阴性杆菌比例明显上升，条件致病菌检出增多，草绿色链球菌群、肠道致病菌和甲型副伤寒沙门菌的检出则下降（P<0.01）。结论该院菌群变迁符合现代感染基本特点；条件致病菌增多对许多感染性疾病的防治更为不利。

Abstract:

ObjectiveTo study the distribution and change of microbial population of clinical isolated bacteria from a hospital in recent 10 years. MethodsBacterial culture results of  60 846 clinical samples (blood, urine ,throat swab,sputum,stool , vagina swab,and sterile body fluid) from  inpatients and outpatients between January,1999 and December,2008 were analysed retrospectively.ResultsThese isolates included 67 genus 207 species 18 674  strains of bacteria, the isolation rate was 30.69%(18 674/60 846), the ratio of gramnegative bacillus to grampositive coccus and fungus was 54.42∶32.21∶11.56. The major bacteria were Salmonella paratyhi A, Viridans streptococci, Escherichia coli, yeastlike fungi ,coagulase negative Staphylococcus and Staphylococcus aureus. The proportion of gramnegative bacillus rose obviously, so did the opportunistic pathogens.  The isolation rates of Viridans streptococcus and enteric pathogens and Salmonella paratyhi A  decreased (P<0.01). ConclusionChange in  floral  is in accordance with fundamental characteristics  of presentday infection; The increase of opportunistic pathogens  is disadvantageous to the prevention and treatment of multiple  infectious diseases.