鲍曼不动杆菌肺部感染的临床特点及耐药性分析 FREE

Clinical characteristics and drug resistance of Acinetobacter baumannii pulmonary infection FREE

摘要:

目的分析和总结鲍曼不动杆菌肺部感染的临床特点及耐药规律。方法对2006年6月—2008年6月间住院的65例鲍曼不动杆菌肺部感染患者临床资料进行分析。结果鲍曼不动杆菌肺部感染在综合重症监护病房（ICU，41.54%）、神经内科监护病房（29.23%）、神经外科监护病房（10.77%）、呼吸内科（10.77%）较常见；对多种抗菌药物的耐药率＞70%；感染患者大多为年老体弱、基础疾病多、住院时间长且接受各种侵入性操作、感染前反复使用2种以上抗菌药物者；部分病例合并其他病原菌感染，以铜绿假单胞菌（34.55%）及嗜麦芽窄食单胞菌（20.00%）较多。结论鲍曼不动杆菌肺部感染患者病情重，对抗菌药物耐药率高，掌握其临床特点、感染分布及耐药规律，对临床预防与治疗尤为重要。

Abstract:

ObjectiveTo analyze the  clinical characteristics and drug resistance of Acinetobacter baumannii (A.baumannii)  pulmonary infection. MethodsClinical data of 65 cases of A.baumannii pulmonary infections in a hospital from June, 2006 to June, 2008 were analyzed.ResultsThe incidence rate of A.baumannii infections were high in general  intensive care unit (ICU, 41.54%), neurological ICU （29.23%）,  neurosurgical ICU (10.77%), and respiratory department(10.77%);Resistant rates to many kinds of antimicrobial agents were >70%.The infected patients were almost aged, with many underlying diseases, with long hospitalization time and various invasive treatment, as well as receiving  at least 2 kinds of antimicrobial agents before developing infection; some patients complicated with infections caused by the other pathogens,  most were Pseudomonas aeruginosa (34.55%) and Stenotrophomonas maltophilia(20.00%) infections.  ConclusionPatients with A.baumannii infections are in serious condition, antimicrobial  resistance is high, realization of  the clinical characteristics, infection distribution and drug resistance pattern are important to prevent and treat  infections .