Abstract:Objective To evaluate the risk and window period of the occurrence of central line-associated bloodstream infection (CLABSI), analyze the effect of applying multidisciplinary team (MDT) management to reduce CLABSI, and provide evidence for the formulation of prevention and control strategies for CLABSI. Methods All hospitalized patients with central venous catheter (CVC) in the intensive care unit (ICU) of a tertiary first-class hospital were selected from January, 2019 to December, 2022. A two-stage, single-center, pre- and post-control real-world study was adopted. The first stage (from January, 2019 to December, 2020) was the baseline control stage, and the second stage (from January, 2021 to December, 2022) was the intervention stage. The project team used MDT management method to continuously strengthen organizational management, improve work processes, and prospectively monitor the risk of the occurrence of CLABSI by using the independently developed "CLABSI whistle system". In addition, according to the actual risk situation, a mechanism of cross-checklist was added to CLABSI bundle prevention and control strategy within 7 days after CVC intubation. Results The incidence of CLABSI at baseline stage was 9.16% and the daily incidence was 10.75‰. The incidence of CLABSI in the intervention period was 5.99% and the daily incidence was 6.48‰. The incidence and daily incidence of CLABSI before and after intervention were statistically different (both P<0.001). The acute onset period of CLABSI was 7-9 days after CVC intubation, afterwards the risk turned stable. The project team successfully reduced the risk of CLABSI through intervention within 7 days after intubation (χ2=19.130, P＜0.001). Conclusion 7-9 days after CVC intubation is the window of opportunity to reduce CLABSI, and grasping this period can effectively reduce the risk of CLABSI.