Abstract:The global morbidity and mortality of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are gradually decreasing, but the elderly people are still at higher risk of death than the general population, especially for those with Alzheimer’s disease (AD) . AD is a slowly progressing degenerative disease of the nervous system, and is the most common type of dementia. Its neuropathological features include overproduction and clea-rance imbalance of amyloid β-protein and overphosphorylated tau protein leading to neurofibrillary tangle. People with AD are more susceptible to be infected with SARS-CoV-2, likewise, the virus can also cause AD in those who are infected. After SARS-CoV-2 infection, it affects AD through immune response, inflammatory response, cell aging, DNA damage reaction, autophagy disorder, choroidal homeostasis disorder, over-activation of renin-angiotensin system, and oxidative stress. This article mainly reviews the research progress in the effect of SARS-CoV-2 infection on AD.