Research progress on antiviral effects of immunosuppressants

Abstract:

Immmunosuppressants are mainly used to reduce rejection after solid organ transplantation, so as to improve the success rate of organ transplantation. However, long-term use of immunosuppressants can also seriously impair the immune function of patients, thereby increasing the risk of viral infection and postoperative complications, leading to transplant failure. Therefore, patients need to use both immunosuppressants and antiviral agents. If some immunosuppressants with antiviral effects are found, the patient’s burden of taking medicines will be greatly reduced. Currently, the immunosuppressants with antiviral effect have been focused by researchers. The gradual revealing of the antiviral mechanism of these immunosuppressants will help to optimize the treatment plan of postope-rative rehabilitation of organ transplant recipients. Based on the mechanism of rejection of transplanted organ, this paper systematically describes the types of viruses which closely related to infection of organ transplant patients and the molecular mechanism of some immunosuppressants in antiviral aspects, which further provides a new idea for clinical prevention and treatment of viral infection due to organ transplantation.