Clinical characteristics and prognosis of community-acquired carbapenem-resistant Klebsiella pneumonia bloodstream infection

Abstract:

Objective To evaluate the clinical characteristics and prognosis of community-acquired carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection. Methods Klebsiella pneumoniae bloodstream infection cases in a hospital from February 2017 to March 2021 were analyzed retrospectively, according to antimicrobial susceptibility testing results, they were divided into carbapenem resistance group (CRKP group) and carba-penem susceptibility group (CSKP group), clinical characteristics and 30-day prognosis of two groups of patients were compared. Results There were significant differences between two groups of patients in terms of coronary heart disease or heart failure, chronic obstructive pulmonary disease, recent hospitalization history, chronic renal insufficiency, anemia, deep vein catheterization, mechanical ventilation, indwelling gastric tube, and urinary catheterization, CRKP group was higher than CSKP group (all P < 0.05). The 30-day mortality in CRKP group was higher than that in CSKP group (58.82% vs 9.68% P < 0.001). Conclusion Community-acquired CRKP bloodstream infection accounts for a high proportion of patients with cardiopulmonary and renal underlying diseases as well as recent hospitalization history, prognosis of CRKP group is poor, which should be paid clinical attention.