Trial sequential analysis on effectiveness in the management of central line-associated bloodstream infection

Abstract:

Objective To evaluate the management effectiveness of infection control intervention measures in preventing central line-associated bloodstream infection (CLABSI). Methods The domestic studies on prevention and control of CLABSI in domestic and foreign databases from January 2010 to December 2020 were retrieved through computer system, the reported data in the original study were extracted, OR value and 95% confidence interval (CI) were combined, intervention methods were summarized. Results A total of 263 studies were retrieved, 142 of which were included in the final analysis, prevention and control of CLABSI in recent 10 years has achieved remar-kable results (OR=0.26, 95%CI: 0.24-0.29), about 68.53% of CLABSI can be prevented. There is no heterogeneity among studies, a total of 43 614 patients are involved, far exceeding the cut off points of trial sequential analysis. Conclusion Prevention and control of CLABSI in China has achieved remarkable results in recent ten years, there is no need to carry out more trial to prove it, follow-up quality improvement study can be carried out according to the 2021 guidelines, further reduce the rate of vascular catheter-associated infection.