Abstract:Objective To surveil the distribution and antimicrobial susceptibility of clinically isolated bacteria from outpatients in China from 2014 to 2019. Methods According to China Antimicrobial Resistance Surveillance System (CARSS) program, clinically isolated bacteria and antimicrobial susceptibility testing results of outpatients reported by all CARSS member hospitals in 2014-2019 were analyzed by WHONET 5.6 software. Results The total number of bacteria isolated from outpatients in 2014-2019 were 53 243-91 692 strains, Gram-negative bacteria accounted for 75.3%, 57.3%, 58.3%, 58.5%, 60.5% and 60.9% respectively, Gram-positive bacteria accounted for 24.7%, 42.7%, 41.7%, 41.5%, 39.5% and 39.1% respectively. Isolation rates of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase negative Staphylococcus (MRCNS) were 25.1%-27.8% and 68.3%-72.4% respectively. Resistance rates of MRSA and MRCNS to most antimicrobial agents were higher than those of methicillin susceptible strains, vancomycin-, teicoplanin- and linezolid-resistant strains were not found. Resistance rates of Enterococcus faecalis to most tested antimicrobial agents were lower than those of Enterococcus faecium, and both had a few vancomycin-resistant strains. Resistance rate of Streptococcus pneumoniae isolated from non-cerebrospinal fluid specimens to penicillin were 1.0%-2.3%. Resistance rates of Pseu-domonas aeruginosa and Acinetobacter baumannii to imipenem were 10.7%-15.2% and 38.5%-49.4% respectively; resistance rates of Escherichia coli to cefotaxime and imipenem were 48.0%-55.6% and 0.6%-0.8% respectively; resistance rates of Klebsiella pneumoniae to cefotaxime and imipenem were 31.0%-38.3% and 3.9%-6.3% respectively. Resistance rates of Haemophilus influenzae to ampicillin were 37.5%-55.6%. Conclusion Antimicrobial resistance of clinically isolated bacteria from outpatients is still serious, especially carba-penem-resistant Gram-negative bacilli and methicillin-resistant Staphylococcus.