Advances of mammalian mechanistic target of rapamycin inhibitors in reducing human cytomegalovirus infection in renal transplantation recipients
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R699.2;R373.1+1

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    Abstract:

    Human cytomegalovirus(HCMV) is one of the eight herpes viruses that can infect human, it often infects people with low immunity, especially in patients after renal transplantation, patients with advanced acquired immunodefiency syndrome, and newborns. Mammalian mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase(AKT) of the downstream of acid-inositol-3-kinase (PI3K) family, which can affect all stages of HCMV infection. mTOR inhibitor(mTORi)can be used as immunosuppressant in patients after renal transplantation, it can reduce incidence of HCMV infection. This paper reviews the advance of mTORi in reducing HCMV infection in renal transplantation recipients.

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张帆, 邢益平.哺乳动物雷帕霉素靶蛋白抑制剂降低肾移植受者人巨细胞病毒感染的研究进展[J].中国感染控制杂志英文版,2020,19(7):666-670. DOI:10.12138/j. issn.1671-9638.20205846.
ZHANG Fan, XING Yi-ping. Advances of mammalian mechanistic target of rapamycin inhibitors in reducing human cytomegalovirus infection in renal transplantation recipients[J]. Chin J Infect Control, 2020,19(7):666-670. DOI:10.12138/j. issn.1671-9638.20205846.

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  • Received:September 29,2019
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  • Online: July 28,2020
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