Abstract:A 58-year-old male patient was admitted to hospital because of repeated double hip pain for 20 days. After repeated "double hip incision and drainage" in the local hospital, patient was transferred to another hospital. The results of secretion and joint fluid culture showed Burkholderia pseudomallei(B. pseudomallei). Patient experienced the failure of conservative treatment, such as antimicrobial treatment, dressing change, as well as catheter lavage and drainage. Double hip X-ray re-examination showed that double hip joint was severely damaged, exclusion treatment of bilateral hip resection and phase Ⅱ total hip arthroplasty were performed, sensitive antimicrobial agents were given at the same time. After 2 years of post-operative follow-up, joint function recovered and no infection recurred. Therefore, in the clinical treatment of chronic suppurative arthritis, first of all, it requires active bacterial culture and identification as well as selection of sensitive antimicrobial agents, secondly, it is necessary to strictly abide by indications of surgery, in view of bone and joint infection, debridement, lavage and drainage should be performed thoroughly in time, phase I and Ⅱ arthroplasty can be performed as long as severe joint damage or loss of function occur.