Abstract:Objective To analyze risk factors for healthcare-associated Candida infection(Candida HAI) in pedia-tric inpatients. Methods Patients with fungal HAI in a hospital from January to December 2018 were selected as infection group, according to 1:1 matching method, patients without fungal infection in the same ward at same admission period and of same age group were randomly selected as control group, Candida HAI and risk factors in infected patients were analyzed. Results From January to December 2018, there were 50 patients with fungal HAI in department of pediatrics, and 50 cases were successfully matched in control group. Among 50 cases of fungal HAI, 23 cases were in department of pediatric general surgery. A total of 68 strains of fungi were isolated, mainly Candida parapsilosis (n=28, 41.18%), followed by Candida tropicalis (n=12, 17.65%), and Candida albicans (n=11, 16.18%). Department of pediatric general surgery ranked first in the number of isolated fungi(n=27), the main type of fungal HAI was bloodstream infection (n=38, 76.00%). Univariate analysis showed that the incidence of HAI was higher in patients with length of hospital stay ≥ 21 days, gastrointestinal surgery, duration of antimicrobial use>2 weeks, tracheal intubation, bacteremia, and intravenous hyperalimentation; multivariate analysis showed that antimicrobial use>2 weeks and tracheal intubation were independent risk factors for fungal HAI in pediatric inpatients. Resistance rates of Candida parapsilosis, Candida tropicalis, Candida albicans, and Candida lusitaniae to amphotericin B and fluorcytosine were all high (82.14%-100.00%). Conclusion The main pathogen of fungal HAI in pediatric inpatients is Candida parapsilosis, which mainly occurs in department of pedia-tric surgery, antimicrobial use>2 weeks and tracheal intubation can increase the risk of fungal HAI in pediatric inpatients, effective nursing measures can improve the prognosis of patients.