Detection and analysis of antimicrobial susceptibility of Cryptococcus neoformans isolated from patients with acquired immunodeficiency syndrome in Yunnan Province
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R512.91;R446.5

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    Abstract:

    Objective To investigate antimicrobial susceptibility of Cryptococcus neoformans (C. neoformans) isolated from patients with acquired immunodeficiency syndrome(AIDS) in Yunnan Province. Methods 304 strains of C. neoformans isolated from AIDS patients in Yunnan Infectious Diseases Hospital between August 2007 and July 2018 were performed antimicrobial susceptibility testing by colorimetric microdilution method, susceptibility to 6 commonly used anti-cryptococcal agents was detected. Results Antimicrobial susceptibility testing results showed that MIC50 of amphotericin B, 5-fluorocytosine, fluconazole, voriconazole, itraconazole, and posaconazole were 1, 2, 4, 0.03, 0.06, and 0.12 μg/mL respectively, and the MIC90 were 1, 4, 8, 0.06, 0.12, and 0.25 μg/mL respectively, with geometric mean values of 0.75, 2.32, 3.28, 0.039, 0.053, and 0.09 μg/mL respectively. Among 6 antifungal agents, resistance rate of C. neoformans to voriconazole and amphotericin B was 1.32%, and to 5-fluorocytosine was 0.33%, no strain was found to be resistant to itraconazole and fluconazole. Conclusion C. neoformans isolated from AIDS patients in Yunnan Province have different susceptibility to different antimicrobial agents, which can provide reference for clinical antimicrobial choice.

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樊红丽, 高丽, 毛小琴,等.云南省艾滋病患者分离新生隐球菌的药物敏感性检测与分析[J].中国感染控制杂志英文版,2019,18(4):340-343. DOI:10.12138/j. issn.1671-9638.20194274.
FAN Hong-li, GAO Li, MAO Xiao-qin, et al. Detection and analysis of antimicrobial susceptibility of Cryptococcus neoformans isolated from patients with acquired immunodeficiency syndrome in Yunnan Province[J]. Chin J Infect Control, 2019,18(4):340-343. DOI:10.12138/j. issn.1671-9638.20194274.

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History
  • Received:September 20,2018
  • Revised:
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  • Online: April 28,2019
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