Abstract:ObjectiveTo study clinical efficacy of ganciclovir in the therapy of infectious mononucleosis in adults. Methods66 adults with infectious mononucleosis in a hospital from January 2010 to December 2014 were studied retrospectively, according to drug therapy, patients were divided into ganciclovir therapy group (n=31) and symptomatic therapy group (n=35), clinical features before therapy, therapeutic efficacy, and EpsteinBarr virus(EBV) DNA negative conversion time were analyzed. ResultsThe time of defervescence, sore throat improvement, EBVDNA negative conversion, subside of enlarged lymph node, and transaminase recovery in ganciclovir therapy group were all shorter than symptomatic therapy group(all P<0.05). Blood routine recovery time between two groups was not significantly different(P>0.05). ConclusionGanciclovir has a good antiviral effect on the therapy of adult infectious mononucleosis, it can rapidly relieve patients from clinical symptoms including fever, sore throat and so on.
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