Abstract:ObjectiveTo understand the occurrence of totally implantable venous access port（TIVAP）related infection, and explore its risk factors.MethodsA total of 2 098 patients with breast cancer who received TIVAP in a tertiary firstclass hospital in Henan Province between January 2013 and December 2016 were selected as the research subjects. By nested case control study, 26 patients with TIVAPrelated infection during monitoring period were selected as case group, according to the proportion of 1∶2, 52 patients undergoing the same kind of operation during the same period were randomly selected as control group, difference in general data and research indexes between two groups was compared. Logistic regression model was used to analyze the risk factors for TIVAPrelated infection.ResultsDuring monitored period, the total TIVAP day was 274 838 days, 26 patients developed TIVAPrelated infection, incidence of TIVAPrelated infection was 1.24%, infection rate per 1 000 venous access day was 0.09‰; the main pathogen causing infection was Staphylococcus epidermidis (30.77%); independent risk factors for TIVAPrelated infection in patients were history of diabetes mellitus (OR, 3.61 ［95%CI, 1.27-10.11］), duration of venous access≥90 days (OR, 4.71 ［95%CI, 1.65-13.22］), and duration of operation≥40 minutes (OR, 3.60 ［95%CI, 1.34-9.64］). ConclusionIt is necessary to strengthen the monitoring and followup of patients receiving TIVAP, especially for patients with diabetes mellitus, as well as long duration of catheterization and operation, so as to prevent and control TIVAPrelated infection.