Abstract:ObjectiveTo understand direct economic loss due to healthcareassociated infection(HAI) with multidrugresistant Acinetobacter baumannii(MDRAB). Methods65 hospitalized patients with MDRAB in a tertiary firstclass general hospital in Chongqing City between September 2014 and August 2016 were as case group, a 1∶1 matched casecontrol study was adopted, 65 hospitalized patients without HAI during the same period were selected as control group, direct economic loss due to MDRAB HAI was analyzed and compared. ResultsThe median of hospitalization expense, medicine proportion, and length of hospital stay in case group were 167 579.56 yuan, 37.40%, and 52 days respectively, while those in control group were 59 386.77 yuan, 31.85%, and 27 days respectively, the average direct economic loss due to MDRAB HAI was 108 192.79 yuan, mainly for fees of medicine, nursing, treatment, and laboratory detection, the proportion of medicine was the highest; the average extension of length of hospital stay due to MDRAB HAI was 25 days; each expense in case group was higher than that of control group, difference were all statistically significant (all P<0.05). ConclusionEconomic loss due to MDRAB HAI is serious, proportion of medicine is increased, and length of hospital stay is prolonged, prevention and control should be paid attention.