Abstract:ObjectiveTo explore risk factors for peripherally inserted central catheterrelated bloodstream infection(PICCCRBSI)in patients with tumor. MethodsPatients with PICC and had accessible complete information from central venous catheter registry database in a tertiary firstclass hospital in Jingzhou City between February 2015 and February 2017 were chosen. 48 tumor patients with PICCCRBSI were performed 1∶1 matched casecontrol study, the main risk factors were screened through logistic regression analysis. ResultsThere were 1 357 patients with PICC, 698 were recruited in the study, 48 cases had PICCCRBSI, incidence was 6.88%; the total PICC days were 13 953 days, incidence was 3.44 per 1 000 catheter days. No.of puncture ≥3(OR=2.05), positioning of chest Xray (OR=4.23), and without timely maintenance (OR=2.17) were independent risk factors for PICCCRBSI.ConclusionPICCCRBSI is related to No. of puncture, positioning method and maintenance frequency, the occurrence of PICCCRBSI can be decreased by reducing the No. of puncture, positioning by electrocardiogram (EKG) during catheterization process, and timely maintenance.