Distribution and antimicrobial resistance of pathogens causing soft tissue infection in children
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    Abstract:

    ObjectiveTo explore distribution and antimicrobial resistance of pathogens causing soft tissue infection (STI) in children. MethodsChildren with STI and had positive bacterial culture in a hospital between January 2010 and January 2017 were analyzed, they were divided into communityassociated STI group(CASTI) and healthcareassociated STI(HASTI) group, pathogens and antimicrobial resistance of pathogens causing STI were analyzed. ResultsA total of 165 STI patients were with positive bacterial culture. There were 98 cases in CASTI group and 67 in HASTI group. 16 kinds of bacteria were isolated. 98 cases of CASTI were single bacterial infection, 92 of which were grampositive bacteria, mainly Staphylococcus aureus (S. aureus, n=85, 86.7%) and Streptococcus pyogenes (n=4, 4.08%); 6 strains were gramnegative bacteria, mainly Escherichia coli(E. coli, n=3, 3.06%) and Klebsiella pneumoniae(n=2, 2.04%). 67 cases were HASTI, 5 cases were mixed infection with two kinds of bacteria, 72 strains of bacteria were isolated, 13 were grampositive bacteria strains, mainly S. aureus (n=9, 12.50%);59 were gramnegative bacteria, mainly E. coli (n=21, 29.17%), Pseudomonas aeruginosa (P. aeruginosa, n=15, 20.83%), and Enterobacter cloacae(E. cloacae, n=13, 18.06%). Resistance rates of S. aureus to penicillin, erythromycin, and lincomycin were all>50%,resistance rates to gentamicin, compound sulfamethoxazole, and rifampicin were all <20%,isolation rate of methicillinresistant S. aureus (MRSA) was 43.62%, strains were all sensitive to vancomycin, linezolid, tigecycline, levofloxacin, moxifloxacin, and nitrofurantoin. Resistance rates of E. coli to cefuroxime and sulfamethoxazole were all >70%,resistance rates to piperacillin, cefepime, and levofloxacin were all <30%, imipenemresistant E. coli and P. aeruginosa were not found. ConclusionS. aureus is the main pathogen causing CASTI in children; the main pathogens of HASTI are E. coli, P. aeruginosa, E. cloacae, and other gramnegative bacteria. Children with STI can choose antimicrobial agents according to types of infection before pathogens are identified.

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张天久,俞松,杨小红,等.儿童软组织感染病原菌分布及其耐药性[J].中国感染控制杂志英文版,2018,17(5):436-439. DOI:10.3969/j. issn.1671-9638.2018.05.015.
ZHANG Tianjiu, YU Song, YANG Xiaohong, et al. Distribution and antimicrobial resistance of pathogens causing soft tissue infection in children[J]. Chin J Infect Control, 2018,17(5):436-439. DOI:10.3969/j. issn.1671-9638.2018.05.015.

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History
  • Received:July 24,2017
  • Revised:September 25,2017
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  • Online: May 28,2018
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