Abstract:ObjectiveTo explore the necessity of opening nephrostomy tube for patients with septic shock following the indwelling doubleJ stent of postpercutaneous nephrolithotomy (PCNL), and provide reference for the treatment of septic shock after PCNL. Methods60 patients with septic shock after PCNL in a hospital from January 1, 2015 to December 30, 2016 were chosen, patients were randomly divided into clipping nephrostomy tube group (clipping group, n=30) and opening nephrostomy tube group (opening group, n=30), clinical data of two groups of patients were collected and analyzed. ResultsAfter 24hour treatment, heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO2), serum lactate (Lac), and hourly urine volume all improved in both groups of patient compared with pretreatment(all P<0.05); HR, MAP, SpO2, Lac, and hourly urine volume in opening group after 24hour treatment were all significantly different from clipping group (all P<0.05). Levels of serum procalcitonin (PCT) and Creactive protein (CRP) in two groups after 3day treatment decreased significantly compared with pretreatment (both P<0.05); PCT and CRP levels in opening group after 3day treatment were both significantly lower than clipping group (both P<0.05); cure rate of two groups were both 100.00%, hospitalization time and extubation time in opening group were both shorter than clipping group, and cost was less than clipping group, difference were all significant(all P<0.05). ConclusionOpening nephrostomy tube on the basis of indwelling doubleJ stent is necessary for patients with septic shock after PCNL.