Abstract:ObjectiveTo explore the effect of SixSigma management on prevention and control of catheterrelated bloodstream infection(CRBSI) in intensive care unit(ICU). MethodsPatients with indwelling central venous catheter in the ICU of a hospital in MarchDecember 2015 were selected, five phases of SixSigma(define, measure, analyze, improve, and control) were used to find out the key factors that affected CRBSI, targeted improvement measures were taken, incidence of CRBSI before and after adopting SixSigma was compared. ResultsAfter SixSigma management was adopted, incidence of CRBSI declined from 15.95‰(13/815) to 6.19‰(4/646), difference was significant(P<0.05). ConclusionSixSigma management can reveal the defect in workflow, guide researchers to propose corresponding measures, and effectively reduce the incidence of CRBSI in ICU.