Abstract:ObjectiveTo investigate the distribution and drug susceptibility of vaginal pathogens in pregnant women during perinatal period.MethodsVaginal discharge specimens of 10 800 women (5 400 were pregnant women during perinatal period, 5 400 were nonpregnant women) were performed bacterial culture and drug susceptibility testing. ResultsThe isolation rate of pathogens from 5 400 perinatal pregnant women was 26.00% (n=1 404), including 759 strains of fungi, 611 strains of grampositive cocci, 32 strains of gramnegative bacilli, 2 strains of Neisseria gonorrhoeae; among 5 400 nonpregnant women, the isolation rate of pathogens was 7.87% (n=425), including 232 strains of fungi, 182 strains of grampositive cocci, 5 strains of gramnegative bacilli, and 6 strains of Neisseria gonorrhoeae. Resistance rates of Streptococcus agalactiae isolated from perinatal pregnant women to erythromycin and clindamycin were 84.85% and 80.81% respectively,resistance rate of Staphylococcus aureus to erythromycin was 40.91%, resistance rates of Escherichia coli to tetracycline and sulfamethoxazole/trimethoprim were 69.23% and 53.85% respectively, resistance rate of Neisseria gonorrhoeae to penicillin and sulfamethoxazole/trimethoprim was 100.00%. ConclusionVaginal infection rate in perinatal pregnant women is higher than nonpregnant women, screening of vaginal pathogens in perinatal pregnant women should be strengthened, so as to ensure the safety of mothers and infants.