Changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in 2012-2015

Abstract:

ObjectiveTo investigate the changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in a hospital in 2012-2015. MethodsPathogenic bacteria isolated from blood culture in a hospital microbiology laboratory between January 2012 and December 2015 were collected and divided into 2012-2013 group and 2014-2015 group, distribution characteristics, constitute, and antimicrobial susceptibility of two groups were compared. ResultsGramnegative bacteria were the main pathogens isolated during two periods, accounting for 54.96% and 54.66% respectively, there was no significant differences in pathogen distribution between two groups (P>0.05). Grampositive cocci had a high sensitivity to vancomycin and linezolid, resistant rates were both 0; resistance rates of coagulase negative staphylococci to oxacillin were all >80%, resistance to penicillin was also >90%; Enterobacteriaceae was highly sensitive to imipenem and meropenem, but resistance strains had appeared; Acinetobacter baumannii was sensitive to minocycline during two periods, resistance rates were 35.90% and 34.55% respectively, resistance rates to other antimicrobial agents were also high (>75%). ConclusionThe isolation rate of drugresistant pathogenic strains causing bloodstream infection is high, monitoring on bacterial resistance is helpful for guiding rational use of antimicrobial agents in clinic.