RANTES, MCP-1, and SDF-1β levels in healthy people and AIDS patients: a comparative analysis
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R512.91

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    Abstract:

    ObjectiveTo evaluate the differences of serum RANTES(regulated on activation, normal T cell expressed and secreted), MCP1 (monocyte chemoattractant protein), and SDF1β (stromal cellderived factor1β) in patients with acquired immunodeficiency syndrome (AIDS) and healthy people. Methods38 AIDS patients who were admitted to a hospital between January 2010 and January 2015 were as AIDS groups, 38 healthy persons were as a healthy group, serum levels of RANTES, MCP1, and SDF1β in two groups were detected, and the subgroup analysis was carried out according to the viral load. ResultsSerum levels of RANTES, MCP1, and SDF1β in AIDS group were (1 392.55±227.69)pg/mL,(450.91±103.04)pg/mL, and(104.82±22.52)pg/mL respectively,all were significantly higher than those in healthy group([120.58±55.87] pg/mL, [74.25±33.62] pg/mL, and [39.04±11.43]pg/mL respectively)(all P<0.05). Among AIDS patients with HIV viral load 4≤Log(VL)<5 and Log(VL)≥5, serum RANTES were (1 470.34±155.01)pg/mL and (1 408.29±181.54)pg/mL respectively,which were both significantly higher than patients with HIV viral load Log(VL)<4([1 183.12±174.54]pg/mL);serum MCP1 and SDF1β levels in AIDS patients with HIV viral load 4≤Log (VL)<5 were (537.93±89.32)and(149.31±18.05)pg/mL respectively,which were significantly higher than patients with HIV viral load Log(VL)≥5([410.26±80.57] pg/mL, [81.53±20.31]pg/mL respectively) and HIV viral load Log(VL)<4([381.71±77.26] pg/mL, [72.90±21.62]pg/mL respectively), differences were both statistically significant(both P<0.05).ConclusionSerum levels of RANTES, MCP1, and SDF1β are significantly increased in AIDS patients, which are related to the level of viral load.

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邝建玉,瞿志军,赵蔚,等. RANTES、MCP-1和SDF-1β在正常人体和AIDS患者体内含量的对比研究[J].中国感染控制杂志英文版,2017,16(9):841-844. DOI:10.3969/j. issn.1671-9638.2017.09.012.
KUANG Jianyu, QU Zhijun, ZHAO Wei, et al. RANTES, MCP-1, and SDF-1β levels in healthy people and AIDS patients: a comparative analysis[J]. Chin J Infect Control, 2017,16(9):841-844. DOI:10.3969/j. issn.1671-9638.2017.09.012.

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History
  • Received:November 25,2016
  • Revised:February 12,2017
  • Adopted:
  • Online: September 13,2017
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