Abstract:ObjectiveTo evaluate the differences of serum RANTES(regulated on activation, normal T cell expressed and secreted), MCP1 (monocyte chemoattractant protein), and SDF1β (stromal cellderived factor1β) in patients with acquired immunodeficiency syndrome (AIDS) and healthy people. Methods38 AIDS patients who were admitted to a hospital between January 2010 and January 2015 were as AIDS groups, 38 healthy persons were as a healthy group, serum levels of RANTES, MCP1, and SDF1β in two groups were detected, and the subgroup analysis was carried out according to the viral load. ResultsSerum levels of RANTES, MCP1, and SDF1β in AIDS group were (1 392.55±227.69)pg/mL,(450.91±103.04)pg/mL, and(104.82±22.52)pg/mL respectively,all were significantly higher than those in healthy group([120.58±55.87] pg/mL, [74.25±33.62] pg/mL, and [39.04±11.43]pg/mL respectively)(all P<0.05). Among AIDS patients with HIV viral load 4≤Log(VL)<5 and Log(VL)≥5, serum RANTES were (1 470.34±155.01)pg/mL and (1 408.29±181.54)pg/mL respectively,which were both significantly higher than patients with HIV viral load Log(VL)<4([1 183.12±174.54]pg/mL);serum MCP1 and SDF1β levels in AIDS patients with HIV viral load 4≤Log (VL)<5 were (537.93±89.32)and(149.31±18.05)pg/mL respectively,which were significantly higher than patients with HIV viral load Log(VL)≥5([410.26±80.57] pg/mL, [81.53±20.31]pg/mL respectively) and HIV viral load Log(VL)<4([381.71±77.26] pg/mL, [72.90±21.62]pg/mL respectively), differences were both statistically significant(both P<0.05).ConclusionSerum levels of RANTES, MCP1, and SDF1β are significantly increased in AIDS patients, which are related to the level of viral load.