Clinical features and antimicrobial resistance of Klebsiella pneumoniae lower respiratory tract infection in children

Abstract:

ObjectiveTo explore clinical features and antimicrobial resistance of Klebsiella pneumoniae (K. pneumoniae) lower respiratory tract infection(LRTI) in children. MethodsClinical data of 107 children with K. pneumoniae LRTI confirmed by sputum culture from January to December 2015 were analyzed retrospectively. Results62.62% of children with LRTI were aged less than 6 months and 64.49% episodes occurred in autumn and winter. All cases had cough and 39 had fever, the main complications were type I respiratory failure, type Ⅱ respiratory failure, cardiac insufficiency, and electrolyte disturbance, 39 cases（36.45%） had complications involving two systems, 5 cases（4.67%）had complications involving three systems，47 cases (43.93%) met the diagnostic criteria of severe pneumonia. 43 cases (40.19%) had primary underlying diseases, the major were congenital heart disease, preterm and low birth weight, and malnutrition. Children with imipenemresistant bacteria infection were more prone to develop extrapulmonary complications than those with nonresistant pathogenic infection. The resistance rate of K. pneumoniae to amikacin was the lowest(9.35%). 90 cases were recovered and markedly effective, 11 cases were effective, 4 cases were not healed and voluntarily discharged from hospital, and 2 cases died. ConclusionChildren aged less than 6 months and with underlying diseases are prone to develop LRTI, and complications are more.