Abstract:ObjectiveTo study the epidemiological characteristics and influencing factors of handfootmouth disease(HFMD) outbreaks in kindergartens, so as to provide reference for control and prevention of HFMD.MethodsPapers published between 2009 and 2015 about HFMD outbreaks in kindergartens were retrieved from Wanfang database and China National Knowledge Infrastructure(CNKI), then collected papers were analyzed.ResultsData about 39 cases of HFMD outbreaks were obtained, 35 cases occurred in 2008-2012, 1 case occurred respectively in 2007, 2013, 2014, and 2015. 33.34% and 23.08% of outbreaks occurred in May and April. Outbreaks lasted 5-52 days, with a median of 11 days, 30.77% of outbreaks lasted more than 2 weeks. The attack rates of the whole kindergartens were 1.90%-39.74%, attack rates of whole kindergartens were 5%-15% among 65.79% of outbreaks，attack rate of whole kindergartens was ＞20% among 13.16% of outbreaks. 85.71% of outbreaks involved more than 20% of classes, 25.71% of which involved all classes. Both EV71 and CoxA16 caused HFMD outbreaks in kindergartens, two kinds of viruses were both detected in some outbreaks; there were no significant difference in attack rate of whole kindergartens, attack rate of classes with highest incidence, class involving rate, and duration of epidemic between EV71 and CoxA16 epidemic groups（all P>0.05）.ConclusionOnce an HFMD outbreak occurred in a kindergarten, epidemic intensity would be high, both EV71 and CoxA16 can cause HFMD outbreak. There is no obvious correlation between class size and attack rate.