Clinical application of combined detection of procalcitonin and highsensitivity Creactive protein in bacterial infection in elderly patients with coronary heart disease
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    Abstract:

    ObjectiveTo compare changes in infectious markers in blood of patients with coronary heart disease (CHD), analyze clinical diagnostic value of procalcitonin (PCT) and highsensitivity Creactive protein (hsCRP) in bacterial infection in patients with  CHD. MethodsPatients with CHD admitted to a hospital between January 2013 and December 2014 were studied. PCT, hsCRP, white blood cell (WBC), and neutrophil (NEU) count were detected before treatment and on the 5th day after treatment, differences between bacterial infected group and noninfected group, infection sites, as well as survival and death groups were compared respectively. ResultsSerum levels of PCT,hsCRP,WBC, and NEU in bacterial infected group were all significantly higher than noninfected group; PCT and hsCRP in infection of different sites were statistically significant (all P<0.001), patients with bloodstream infection had the highest levels ([45.148±46.341] ng/mL, [137.000±87.367]mg/L, respectively),followed by thoracic and abdominal infection,as well as respiratory system infection,while patients with urinary system infection had the lowest levels([0.769±1.747]ng/mL, [53.006±45.450]mg/L, respectively). After treatment, makers in survival group were all lower than before treatment, but in death group were all higher than before treatment. The area under the curve of PCT, hsCRP, WBC, and NEU were 0.934, 0.856, 0.782, and 0.784 respectively. ConclusionThe combined detection of PCT and hsCRP is effective for early diagnosis of bacterial infection in elderly patients with CHD, it is also helpful for assessing disease condition, curative efficacy, and prognosis.

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郭健莲,刘惠娜,肖斌龙,等.降钙素原与高敏C反应蛋白联合检测在老年冠心病患者细菌感染中的临床应用[J].中国感染控制杂志英文版,2016,15(10):748-751. DOI:10.3969/j. issn.1671-9638.2016.10.007.
GUO Jianlian, LIU Huina, XIAO Binlong, et al. Clinical application of combined detection of procalcitonin and highsensitivity Creactive protein in bacterial infection in elderly patients with coronary heart disease[J]. Chin J Infect Control, 2016,15(10):748-751. DOI:10.3969/j. issn.1671-9638.2016.10.007.

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  • Received:January 15,2016
  • Revised:March 22,2016
  • Adopted:
  • Online: October 26,2016
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