Clinical study of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drugresistant Acinetobacter baumannii
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R181.3+2

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    Abstract:

    ObjectiveTo evaluate clinic efficacy and safety of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with  drugresistant Acinetobacter baumannii(DRAB).Methods12 patients with DRAB intracranial infection admitted in a department of neurosurgery between January 2014 and  April 2015 were analyzed retrospectively, clinic efficacy and safety of  tigecycline combined with cefoperazone/sulbactam for treatment of DRAB intracranial infection were evaluated. ResultsAfter patients received tigecycline combined with cefoperazone/sulbactam for 1262 days(39.5 days on average), clinical symptoms and signs(including body temperature,  signs of meningeal irritation)of most patients were significantly improved compared with before treatment,3 cases were cured, 5 were markedly effective, 4  abandoned or ineffective(death). The overall effective rate was 66.67%(8/12),mortality was 33.33%(4/12);bacterial clearance rate of cerebrospinal fluid (CSF) was 83.33%(10/12). Causes of death: 2 were with failure of brain stem following  craniocerebral trauma,1was extensive parenchymal infection,1was recurrence of intracranial infection and formation of  brain abscess after withdrawing antimicrobial agents. No significant adverse reaction occurred during the treatment period. ConclusionOn the basis of keeping CSF drainage unobstructed, long course treatment of tigecycline combined with cefoperazone/sulbactam can effectively eliminate DRAB from CSF, and has a good safety.

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陈红伟,娄元华,李小勇,等.替加环素联合头孢哌酮/舒巴坦治疗耐药鲍曼不动杆菌颅内感染临床研究[J].中国感染控制杂志英文版,2016,15(6):384-387. DOI:10.3969/j. issn.1671-9638.2016.06.005.
CHEN Hongwei, LOU Yuanhua, LI Xiaoyong, et al. Clinical study of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drugresistant Acinetobacter baumannii[J]. Chin J Infect Control, 2016,15(6):384-387. DOI:10.3969/j. issn.1671-9638.2016.06.005.

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  • Received:October 26,2015
  • Revised:December 23,2015
  • Adopted:
  • Online: June 30,2016
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