Distribution and changes in antimicrobial resistance of pathogens from blood culture in a tertiary firstclass hospital in 2012-2015
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R181.3+2

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    Abstract:

    ObjectiveTo investigate the distribution and change in antimicrobial resistance of pathogens causing bloodstream infection, so as to provide reference for rational antimicrobial use. MethodsThe isolation and antimicrobial resistance of major pathogens from blood culture specimens from a tertiary firstclass hospital in 2012-2015 were analyzed statistically. ResultsA total of 4 780 isolates were detected,  the top five species were Escherichia coli  (n=1 008, 21.09%), Klebsiella pneumoniae (n=624, 13.05%),  Acinetobacter baumannii ( n=452, 9.46%),  Staphylococcus aureus ( n=437, 9.14%), and  Pseudomonas aeruginosa (n=247, 5.17%). The percentage of gramnegative bacilli, grampositive cocci, fungi, and others were 62.05%, 29.31%,7.76%, and 0.88% respectively. The resistance rates of Klebsiella pneumoniae to ertapenem and imipenem increased from 4.50% in 2012 to 46.79% and 33.94% in 2015( both P<0.01). The resistance rates of  Acinetobacter baumannii to cefepime, ceftazidime, tobramycin, gentamicin, and imipenem  were 86.50%, 80.56%,78.10%,79.87%, and 84.29% respectively;resistance rates to amikacin in 2012-2015 were 0,10.22%,39.85%, and 21.30% respectively(P<0.01);resistance rates to minocycline in four years were 0-7.52% ( P<0.01). ConclusionThe main pathogens causing  bloodstream infection are gramnegative bacilli,  Acinetobacter baumannii is highly resistant to cephalosporins and carbapenems, resistance rates of Klebsiella pneumoniae to carbapenems increased rapidly. Broadspectrum antimicrobial agents must be used cautiously to reduce the selective pressure of antimicrobial agents.

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刘乐平,刘文恩, 晏群,等.2012—2015年某三甲医院血培养常见病原菌及其耐药性变迁[J].中国感染控制杂志英文版,2016,15(6):374-379. DOI:10.3969/j. issn.1671-9638.2016.06.003.
LIU Leping, LIU Wenen, YAN Qun, et al. Distribution and changes in antimicrobial resistance of pathogens from blood culture in a tertiary firstclass hospital in 2012-2015[J]. Chin J Infect Control, 2016,15(6):374-379. DOI:10.3969/j. issn.1671-9638.2016.06.003.

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  • Received:March 15,2016
  • Revised:April 29,2016
  • Adopted:
  • Online: June 30,2016
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