Abstract:ObjectiveTo investigate the prevalence rate of healthcareassociated infection(HAI) in Xiangya Hospital,and provide reference for preventing and controlling HAI.MethodsThe cross sectional surveys on prevalence rates of HAI, crosssectional antimicrobial use, and bacterial detection among all hospitalized patients on the given days in 2000-2014 (except 2006) were carried out by combination of bedside investigation and medical record reviewing.ResultsThe prevalence rates of HAI in 2000-2014 decreased from 6.30% to 3.91%, difference was statistically significant (χ2=35.14,P<0.001); prevalence rates of communityassociated infection(CAI)were 15.61%-15.76%, there was no significant difference among each year. General intensive care unit (ICU) had the highest prevalence rate; respiratory tract was the most common site of both HAI and CAI; urinary catheterization rate showed a decreased tendency, arteriovenous catheterization rate showed a increased tendency, difference were both significant(χ2=5.21,96.24,respectively, both P<0.001). In 2008-2014, pathogenic detection rates for specimens from patients receiving therapeutic antimicrobial agents were 36.37%-44.51%,from patients with HAI were 34.00%-44.99%,detection rate of pathogens causing HAI were 41.57%-68.48%,all showed a increased tendency, difference was significant (χ2=22.78, 10.03,26.49, respectively, all P<0.001). Gramnegative bacteria were the main pathogens causing infection; both cross sectional and combination antimicrobial usage rates declined (P<0.05).ConclusionPrevention and control of HAI,and antimicrobial management has achieved preliminary success, prevalence rate of HAI and cross sectional antimicrobial usage rate declined obviously, the main pathogen is gramnegative bacteria,and the major infection site is lower respiratory tract.