Characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus isolated from patients in intensive care units
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R181.3+2

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    Abstract:

    ObjectiveTo study the characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus (S. aureus) in the intensive care units(ICUs) of a hospital. MethodsClinical isolates of S. aureus collected from ICUs between January and December 2014 were identified and performed antimicrobial susceptibility testing, then typed by staphylococcal protein A (spa) typing and multilocus sequence typing (MLST) methods. ResultsOf 160 isolates of S. aureus, 120 (75.00%) were methicillinresistant S. aureus (MRSA). Resistance rates of  MRSA to erythromycin, clindamycin,and levofloxacin were all >80%; methicillinsensitive S. aureus (MSSA) were sensitive to cefazolin, resistance rates to erythromycin, clindamycin, and levofloxacin were 62.50%,35.00%, and 10.00%  respectively. spa typing and MLST results showed that the main types of 120 isolates of MRSA were ST239t030,ST239t037, and ST5t2460, the major epidemic strains were ST239t030 (n=105,87.50%), and were isolated from 8 ICUs; MSSA had more types, ST59t437 were detected only from department of neurology(n=8) and department of digestive diseases(n=2), ST6t701,ST398t3625,ST398t1793, and ST121t2092 were isolated  from departments of neurology(n=7),  anesthesiology(n=5), neurosurgery(n=4),and cardiac surgery(n=4)respectively.  ConclusionIsolation rate of MRSA in ICUs in this hospital is high, ST239t030 is the main type, which prevailed in hospital; different types of MSSA have epidemic trends in various departments.

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徐修礼,周珊,白露,等. ICU患者分离金黄色葡萄球菌的耐药性及分子流行病学特征[J].中国感染控制杂志英文版,2016,15(5):294-298. DOI:10.3969/j. issn.1671-9638.2016.05.002.
XU Xiuli, ZHOU Shan, BAI Lu, et al. Characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus isolated from patients in intensive care units[J]. Chin J Infect Control, 2016,15(5):294-298. DOI:10.3969/j. issn.1671-9638.2016.05.002.

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History
  • Received:December 10,2015
  • Revised:February 10,2016
  • Adopted:
  • Online: May 30,2016
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