Abstract:ObjectiveTo evaluate effectiveness of clinical pharmacists’ intervention in perioperative antimicrobial use in type I incisional surgery.MethodsClinical data of 1 398 patients undergoing type I incisional surgery in a hospital between January and December 2014 were analyzed retrospectively, 633 patients who underwent surgery between January and June were as preintervention group, 765 patients who underwent surgery between July and December were as postintervention group (clinical pharmacists were assigned to strengthen the management and control of rational antimicrobial use), antimicrobial prophylaxis between preintervention group and postintervention group were compared.ResultsIn pre and postintervention groups, antimicrobial prophylaxis were 56.71% and 28.37% respectively（χ2=113.26，P＜0.05). Rational selection rates of antimicrobial types were 60.45% and 89.86% respectively, rational rates of administration time were 49.58% and 82.49% respectively, the rates of antimicrobial prophylaxis course≤24 hours were 11.42% and 29.95% respectively，＞24 hours were 88.58% and 70.05% respectively，combination antimicrobial use were 10.31% and 0 respectively，the differences between before and after intervention were all statistically significant (all P＜0.05). Incidence of surgical site infection in preand postintervention groups were 0.79%（5/633）and 0.26%（2/765）respectively（P=0.255）.ConclusionThrough clinical pharmacists’ intervention in perioperative antimicrobial prophylaxis in type I incisional surgery, antimicrobial prophylaxis rate decreased dramatically, antimicrobial management is more standardized, scientific and systematic.