Abstract:ObjectiveTo understand the distribution of multidrugresistant organisms (MDROs) in a cancer hospital, and provide basis for the prevention and control of healthcareassociated infection (HAI).MethodsMonitored data of MDROs from clinical specimens in Guizhou Cancer Hospital in 2011-2013 were analyzed retrospectively.ResultsA total of 1 165 MDRO strains were isolated in 2011-2013, most of which were extendedspectrum betalactamaseproducing Escherichia coli (n=626,53.73%), followed by methicillinresistant coagulase negative staphylococcus (MRCNS, n= 209,17.94%); MDRO detection rate increased year by year. MDROs were mainly isolated from sputum/throat swabs（n=346,29.70%）, secretion（n=322,27.64%）, and urine（n=227,19.48%）; intensive care unit and department of urology were the major departments of emergence of MDROs, accounting for 18.03% (n=210) and 14.85% (n=173) respectively.ConclusionMDROs in this hospital are mainly isolated from respiratory tract, surgical wound, and urinary system, monitoring of highrisk departments and susceptible population should be strengthened, targeted prevention and control measures should be developed to curb the infection and spread of MDROs.