Pathogenic features and risk factors of invasive fungal infection in patients with hematopathy

Abstract:

ObjectiveTo investigate the status of invasive fungal infection(IFI) associated with hematopathy, and evaluate drug resistance and risk factors of fungal infection. Methods1 246 cases of infection occurred in patients in a hospital from 2006 to 2010 were analyzed retrospectively， pathogenic features and risk factors of IFI were analyzed.ResultsThere were 281 cases of fungal infection， and 162 fungal isolates were isolated, the main infection site was respiratory tract(134 isolates,82.72%). Four major Candida were Candida albicans, Candida tropicalis，Candida glabrata, and Candida krusei; in 20062009, the main fungi were Candida albicans, while in 2010, the majority were nonCandida albicans.The resistant rates of four isolated Candida to fluconazole and itraconazole were 5.15% and 4.41% respectively, 6 isolated Candida krusei strains were all resistant to both fluconazole and itraconazole, voriconazoleresistant strain was not found. The independent risk factors for fungal infection were diabetes and duration time of agranulocytosis＞14 days.ConclusionThe proportion of infection caused by nonCandida albicans increased obviously, fluconazole and itraconazoleresistant nonCandida albicans strains have emerged, comprehensive measures should be adopted to prevent IFI actively and treat patients early.