Abstract:ObjectiveTo investigate occupational exposure among health care workers (HCWs) in a tertiary comprehensive hospital, and analyze the causes and preventive measures of occupational exposure. Methods134 cases of occupational exposure among HCWs in a hospital from January 2010 to December 2013 were analyzed. ResultsOf HCWs sustained occupational exposure, doctors, nurses, and technicians accounted for 59.70%, 19.40%, and 9.70% respectively. The main cause for occupational exposure was nonstandardized management of the sharps (46.27%,n=62),followed by unexpected operation(42.54%,n=57)and inadequate protective measures ( 11.19%, n=15);The main exposure mode was sharp injury(94.78%,n=127), mucosal exposure accounted for 5.22% (n= 7); 42.54% of exposure sources were not clear, 57.46% of exposure sources were clear, 35.82%, 12.69%, 3.73%, and 2.24% of which were hepatitis B virus(HBV), hepatitis C virus(HCV), Treponema pallidum(TP), and human immunodeficiency virus(HIV); 2.24%(n=3)of exposure sources were coinfection of HBV and HCV;0.74%(n=1) was coinfection of HIV, HBV,HCV, and TP. 95.52% of occupational exposures were treated correctly. ConclusionThe highrisk population for occupational exposure are nurses, standard occupational precautions and management of the sharps can reduce the occurrence of occupational exposure among HCWs.