Abstract:ObjectiveTo improve microbial specimen detection rate before therapeutic antimicrobial use.MethodsA system of selective targeted management by clinical department was established, before management was as control group(JulySeptember 2013), after management was as intervention group(OctoberDecember 2013), microbial specimen detection in patients before antimicrobial use was compared between before and after management.ResultsOf all hospitalized patients, 11 254 received therapeutic antimicrobial agents, 3 426 were sent specimens for microbial detection, the specimen detection rate was 30.44%; specimen detection rate in control and intervention group was 28.80% and 31.89% respectively ,the difference was significant(χ2=12.71,P<0.05).3 716 patients(46.61%) received restrained antimicrobial therapy, and 1 418 (79.20%) received special antimicrobial therapy, compared with control group, the difference were both significant(χ2=32.86,19.31,respectively, both P<0.05).ConclusionApplying selective targeted management can improve microbial specimen detection rate before therapeutic use of antimicrobial agents.