Pathogens and risk factors of healthcareassociated infection in children with acute leukemia
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R733.7

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    Abstract:

    ObjectiveTo explore the main sites, pathogen distribution and risk factors of healthcareassociated infections (HAI) in children with acute leukemia, and provide scientific evidence for  prevention and treatment.MethodsData  of 828 children with acute leukemia admitted to a hospital in 2011-2012 were collected, infection site, pathogen distribution and risk factors of infection were analyzed.ResultsOf 828 patients, 184 cases and 196 times of HAI occurred with the incidence of 22.22% and 23.67%, respectively. HAI occurred mostly in respiratory tract (52.56%). A total of 96 pathogenic strains were isolated, among which gramnegative and grampositive bacteria accounted for 58.33%(n=56) and 29.17%(n=28) respectively. Univariate analysis revealed that risk factors for HAI were leukemia remission induction chemotherapy,  hospital stay ≥30 days, peripheral leukocyte count (WBC) ≤3×109/L, granulocyte count ≤0.5×109/L, and acute nonlymphocytic leukemia. Multivariate analysis revealed that hospital stay ≥30 days was independent risk factors for HAI.ConclusionChildren with acute leukemia have a high incidence of HAI, infection mainly occurs in respiratory system, and gramnegative bacteria are major pathogens. The incidence of HAI is correlated with remission induction chemotherapy,long length of hospital stay, low WBC, low number of neutrophils, and acute myeloid leukemia.

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丁蓉芳, 孙树梅.急性白血病患儿医院感染病原菌及危险因素分析[J].中国感染控制杂志英文版,2015,14(5):325-328. DOI:10.3969/j. issn.1671-9638.2015.05.010.
DING Rongfang, SUN Shumei. Pathogens and risk factors of healthcareassociated infection in children with acute leukemia[J]. Chin J Infect Control, 2015,14(5):325-328. DOI:10.3969/j. issn.1671-9638.2015.05.010.

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History
  • Received:February 02,2015
  • Revised:March 12,2015
  • Adopted:
  • Online: May 30,2015
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