Abstract:ObjectiveTo analyze the distribution and antimicrobial resistance of pathogens isolated from department of hematology during the past three years.MethodsPathogenic strains isolated from patients hospitalized in a hematology department between January 2011 and December 2013 were collected, antimicrobial susceptibility testing was performed by KirbyBauer disk diffusion method or automatic system, antimicrobial susceptibility testing results were judged according to American Clinical and Laboratory Standards Institute 2011, data were analyzed by WHONET 56 software.ResultsA total of 462 clinical isolates were collected in 2011—2013, including 161 grampositive cocci isolates, 279 gramnegative bacilli, and 22 fungi. Of Staphylococcus spp, detection rate of methicillinresistant coagulase negative Staphylococcus(MRCNS)and methicillinresistant Staphylococcus aureus (MRSA) was 81.37% and 62.50%respectively. The resistant rate of Staphylococcus spp. and Enterococcus spp. to linezolid was 1.69% and 3.57% respectively, resistant rate of Staphylococcus spp. to teicoplanin was 3.39%, vancomycinresistant grampositive coccus was not found. Enterobacteriaceae strains Escherichia coli and Klebsiella pneumoniae were highly susceptible to carbapenems, the sensitivity rates were 97.56%—98.88%; while nonfermentative gramnegative bacilli Pseudomonas aeruginosa and Acinetobacter baumannii strains were obviously resistant to carbapenems,the resistance rates were 38.71%—64.00%.ConclusionAntimicrobial resistance of major pathogenic strains from hematology department is high, antimicrobial agents should be used according to pathogenic distribution characteristics and antimicrobial susceptibility testing results, healthcareassociated infection control should be strengthened to reduce antimicrobial resistant rate