Abstract:ObjectiveTo understand the impact of methicillinresistant Staphylococcus aureus (MRSA) bloodstream infection on the length of hospital stay, hospital mortality, and poor prognosis of patients. Methods357 patients with Staphylococcus aureus (S.aureus) bacteremia in a hospital between January 1,2009 and December 31,2013 were surveyed and analyzed retrospectively. ResultsOf 357 patients, 91 were infected with MRSA and 266 with methicillinsusceptible S.aureus (MSSA). The length of hospital stay was statistically different between MRSA and MSSA group(29 d vs 23 d, P＜0.01）; before infection, length of hospital stay of MRSA group was longer than MSSA group（P＜0.01）; after infection, length of hospital stay was not statistically different between two groups（17 d vs 16.5 d, P=0.92）. Mortality of MRSA group and MSSA group was not statistically different（13.19％ vs 9.02％, χ2=1.28，P=0.26）. The incidence of poor prognosis of MRSA group was higher than MSSA group(29.67％ vs 16.92％, χ2=6.85，P=0.01）. Multivariate analysis results showed that MRSA infection was independent risk factor for poor prognosis (P＜0.01). ConclusionMRSA infection doesn’t contribute to the prolongation of hospital stay, but MRSA bloodstream infection is a risk factor for poor prognosis of patients.