Communityacquired infections and risk factors in patients with diabetes: A Metaanalysis

Abstract:

ObjectiveTo analyze the types and risk factors of communityacquired infections (CAI) in diabetic patients by system analysis method of evidencebased medicine. MethodsChina National  Knowledge Infrastructure (CNKI),  Wanfang database, VIP database were searched by computer,  domestic published researches on CAI and related risk factors in diabetic patients were aggregated, Metaanalysis was conducted by stata 11．0 software.ResultsA total of 12 literatures were included in the study . The average rate of CAI in diabetic patients was 39.55% (22.12%-55.86%). The major infections  were  respiratory system infection（40.74%）, urinary tract infection（27.35%）, tuberculosis（10.80%）, skin and soft tissue infection（9.19%）, and hepatobiliary system infection （5.57%）. Stratified analysis on risk factors revealed that OR and OR95％CI  of chronic complication, age, disease course, glycemic control, gender, type of diabetes, subtype of ketoacidosis was 1.63（ 1.45，1.82）,1.30（1.19，1.42）,1.47（ 1.35，1.61）, 0.68（0.61，0.76）,0.69（0.64，0.75）,1.37（1.13，1.66 ） and 0.87（0.62，1.23）,respectively. There was no publication bias and combined results were stable. ConclusionThe main CAI in diabetic patients are respiratory system infection, urinary tract infection, tuberculosis, skin and soft tissue infection, and so on ;several factors, such as female, older age, longterm  disease course,  poor glycemic control， and complication, can contribute to the increase of CAI in diabetic patients.