Abstract:ObjectiveTo evaluate the effect of improved cleaning and disinfection method for subclavian venipuncture dressing change to prevent catheterassociated infection. Methods120 hospitalized patients with right subclavian venipuncture at an intensive care unit in JanuaryJune 2012 were divided into control group (n=60) and experimental group(n=60) according to venipuncture date. Control group adopted conventional dressing change : disinfected skin at and around puncture point by 2% iodine tincture, then used 75% alcohol for deiodination ; experimental group adopted improved dressing change : Wiped skin at and around puncture point three times by normal saline, cleaned catheter, disinfected skin around puncture point (avoid puncture point) three times by 75% alcohol, disinfected skin at and around puncture point three times by 0.5% iodine tincture , then disinfected catheter . Associated infection rate between two groups were compared . ResultsFocal infection rate and CRBI rate of experimental group were both lower than control group(5.00% vs 16.67% ;1.67% vs 13.33%), the difference was statistically different (P< 0.05). ConclusionEffect of improved dressing method is better than the conventional dressing method, it can effectively prevent occurrence of focal infection and CRBI.