Abstract:ObjectiveTo investigate the prevalence of antiHCV positive among volunteer blood donors in Zhoukou city. MethodsA total of 200 950 blood specimens from voluntary blood donors in Zhoukou from 2007 to 2012 were detected for antiHCV by doubleantibody sandwich enzymelinked immunosorbent assay, results were analyzed. ResultsThe total positive rate of antiHCV was 0.21%(416/200 950), there were significant difference in positive rates of antiHCV among populations of different genders, ages and educational background(χ2=24.01, 142.31,45.8,respectively,all P<0.01), the positive rate of antiHCV in female was higher than that of male ([0.27%,205/75 658] vs [0.17%, 211/125 292]); the positive rate of antiHCV was the lowest in donors aged 21-30 years (0.06%,38/63 719), and highest in donors aged >40 years (0.33%,162/48 871); the lower donors received education, the higher positive rate of antiHCV they had, the positive rate of antiHCV in donors with junior high school education was 0.26%(107/41 154). The positive rate of antiHCV in blood donors decreased gradually from 2007 to 2012(χ2=14.576,P<0.05).ConclusionThe positive rate of antiHCV is low in voluntary blood donors in Zhoukou and is significantly different among different populations.