Difference in drug resistance of pathogens causing early and lateonset ventilatorassociated pneumonia in an intensive care unit
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R181.3+2

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    Abstract:

    ObjectiveTo study the incidence of ventilatorassociated pneumonia(VAP)and antimicrobial resistance of pathogens in an intensive care unit(ICU).MethodsThe occurrence of VAP in hospitalized patients with mechanical ventilation >48 hours between January 2011 and December 2012 were investigated, species and antimicrobial resistance of pathogens causing early onsetVAP (EVAP, mechanical ventilation≤4 d)and lateonset VAP(LVAP,mechanical ventilation >4 d) were compared.ResultsA total of 176 patients were investigated,incidence of VAP was 44.32%(78 cases);With the prolongation of mechical ventilation,incidence of VAP increased gradually (χ2=52.561,P<0.001).The incidence of LVAP was significantly higher than EVAP (58.33% [70/120] vs 14.29% [8/56])(χ2=30.02,P<0.001).A total of 178 pathogens were isolated, gramnegative bacteria,grampositive bacteria and fungi were 104(58.43%),46(25.84%),and 28(15.73%) isolates respectively; 97(54.49%) multidrugresistance/pandrug resistance organisms (MDRO) were isolated. MDRO isolation rate in LVAP patients was higher than EVAP patients([58.86%,n=93] vs [20.00%,n=4]),resistance rate of major pathogens causing LVAP was significantly higher than EVAP patients(all P<0.05).Fungi infection only occurred in LVAP patients, the total antimicrobial resistance rate was 12.14%.ConclusionThe prolongation of mechanical ventilation can increase the incidence of VAP, and resistance rate of pathogen in LVAP is high.

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蒋述科,罗彪峰,李荣明,等.

重症监护病房早发与晚发呼吸机相关性肺炎病原体耐药性差异[J].中国感染控制杂志英文版,2014,13(4):208-211. DOI:10.3969/j. issn.1671-9638.2014.04.004.
JIANG Shuke, LUO Biaofeng, LI Rongming, et al. Difference in drug resistance of pathogens causing early and lateonset ventilatorassociated pneumonia in an intensive care unit[J]. Chin J Infect Control, 2014,13(4):208-211. DOI:10.3969/j. issn.1671-9638.2014.04.004.

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  • Received:August 22,2013
  • Revised:October 23,2013
  • Adopted:
  • Online: April 30,2014
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