Changes and significance of platelet and blood coagulation function in elderly patients with bacteremia

Abstract:

ObjectiveTo evaluate the changes and clinical significance of platelet and blood coagulation function in elderly patients with bacteremia in an intensive care unit (ICU).MethodsTwentyfour elderly patients with bacteremia were detected platelet count (PLT) and blood coagulation function before and after bacteremia occurred, PLT and blood coagulation function were compared among different pathogen infection groups (grampositive coccus, gramnegative bacillus and fungus) and between survival and death group.ResultsAfter bacteremia occurred, PLT count was(144.50±84.10）×109/L, activated partial thromboplastin time(APTT) was (47.04±14.60)s，prothrombin time (PT) was (18.63±8.92)s, and fibrinogen (FIB) was （4.20±0.98）g/L, compared with baseline values (［233．18±78.20］×109/L, ［33.98±7.36］s, ［12.83±2.17］s, ［3.16±0.79］g/L,respectively),the differences were significant （P<0.05）,but thrombin time (TT) was not significant(P>0.05). PLT and blood coagulation function were not significantly different among different pathogen infection groups(P>0.05). PLT in death group was much lower than survival group(［89.60±36.42］×109/L vs ［213.13±76.06］×109/L)（P<0.05）, APTT was higher than survival group(［54.55±13.21］s vs［35.93±7.03］s)（P＜0.05）, both FIB and PT were not significantly different between death and survival group(P>0.05).ConclusionPlatelet and partial blood coagulation function indexes can be used as auxiliary diagnosis of bacteremia in elderly patients, and to some extent, it can judge prognosis.