Adjuvant therapeutic effect of tanreqing on pulmonary infection caused by Acinetobacter baumannii

Abstract:

ObjectiveTo evaluate the effect of herbal tanreqing injection on adjuvant therapy for Acinetobacter baumannii (A. baumannii) pulmonary infection，and provide reference for more effective treatment for pulmonary infection caused by A. baumannii.MethodsFiftytwo intensive care unit patients with A. baumannii pulmonary infection between January 2012 and March 2013 were selected and randomly divided into conventional therapy group(29 cases)and tanreqing adjuvant therapy group(23 cases).Conventional therapy group were treated with antimicrobial agents according to pathogenic microbiological culture and antimicrobial susceptibility testing results; tanreqing adjuvant therapy group were treated with conventional therapy plus tanreqing injection, therapeutic effect of two groups was compared.ResultsAcute physiology and chronic health evaluationⅡ(APACHEⅡ) score and sequential organ failure assessment (SOFA) score of tanreqing adjuvant therapy group decreased more significantly than the conventional therapy group；the ICU length of stay, antimicrobial days within 28 days, mechanical ventilation days were all significantly lower than conventional therapy group（P＜0.05）. Mortality within 28 and 90 days was not significantly different between two groups(P＞0.05).ConclusionTanreqing injection and antimicrobial agents has a synergistic antimicrobial effect, and has certain therapeutic effect on A.baumannii pulmonary infection.