Abstract:ObjectiveTo investigate the perioperative antimicrobial prophylaxis in patients with hip replacement before and after implementing clinical pathway (CP), so as to provide rational and effective clinical management path.MethodsPerioperative antimicrobial prophylaxis in 120 patients with hip replacement in a hospital between January 2008 and December 2011 was surveyed retrospectively. Sixty patients without implementing CP between January 2008 and December 2009 were as preintervention group, and 60 patients with CP between January 2010 and December 2011 were as postintervention group.ResultsThe rate of antimicrobial used 0.5-2 hours before operation and duration of postantimcrobial prophylaxis≤5 days in postintervention group was significantly higher than that of preintervention group respectively (78.33%［47/60］ vs 31.67%［19/60］,P＜0.05；91.67% ［55/60］ vs 5.00%［3/60］，P＜0.05）; The top three used antimicrobial agents in preintervention group were cefoperazone/sulbactam, cefpiramide, and ceftazidime, which were replaced by cefazolin, cefuroxime, and clindamycin in postintervention group; the average duration of antimicrobial use, average length of hospital stay and daily expense of antimicrobial agents decreased from (13.25±1.69) days, (17.55±1.60) days,and(193.22±34.70) yuan in preintervention group to (4.12±0.87) days, (7.83±1.36) days，and (54.03±9.98) yuan in postintervention group respectively, the difference between two groups was statistically significant（all P＜0.01). ConclusionThe implementation of CP can standardize preventive perioperative antimicrobial use in hip replacement patients, shorten the length of hospital stay,and reduce antimicrobial expense.