Abstract:ObjectiveTo analyze vancomycin minimum inhibitory concentration (MIC) in methicillinresistant Staphylococcus aureus (MRSA) isolated from different clinical specimens.MethodsFrom 2010 to 2012, MRSA were identified and vancomycin MIC in MRSA was determined by VITEK 2 COMPACT; vancomycin MIC values were analyzed.ResultsA total of 1 434 isolates of Staphylococcus aureus were detected, including 857 sputum specimens, 239 blood specimens,and 338 other specimens; MRSA isolation rate of all specimens was 41.12% (169/411), 44.96% (214/476) and 48.08% (263/547) respectively. MRSA isolation rate of blood specimens was 29.03%,30.86% and 30.21% respectively, and sputum was 46.89%,51.03% and 57.10% respectively; MRSA isolation rate of sputum was higher than that of blood specimens (χ2= 6.41, 10.36, 21.43 respectively, all P<0.05). All strains were sensitive to vancomycin. The percentage of vancomycin MIC≥1.00 μg/mL in MRSA from blood specimens was 38.89%（7 isolates）,40.00%（10 isolates）and 37.93%（11 isolates）in 2010-2012 respectively(χ2=0.02，P=0.999）,and from sputum specimens was 36.28%（41 isolates）, 40.94%（61 isolates） and 49.73% （92 isolates）respectively（χ2=5.72，P=0.057）.ConclusionThe detection rate of MRSA clinical isolates has shown an increased trend from 2010 to 2012. Detection rate of MRSA from sputum was higher than that of blood specimens; detection rate and vancomycin MIC value of MRSA from sputum specimens increased a little; detection rate and vancomycin MIC value of blood specimens didn’t change obviously.