Effect of mucosolvan bronchoalveolar lavage on stroke patients with pulmonary infection

Abstract:

ObjectiveTo evaluate the effect of mucosolvan bronchoalveolar lavage  on stroke patients with pulmonary infection.MethodsFortytwo stroke patients with pulmonary infection were randomly divided into two groups, normal saline group and mucosolvan group were 21 cases respectively. All  patients were treated with antiinfection, bronchodilatation, aerosol inhalation and intravenous drip of mucosolvan in ICU. Observed indicators included acute physiological and chronic health evaluation (APACHE Ⅱ ) score, Glasgow coma scale (GCS) ,Creaction protein (CPR), and clinic pulmonary infection score (CPIS) in all cases. The number of alveolar lavage ,the average duration of lavage,  aspirated sputum volume, the days in ICU , duration of using ventilators and CPIS were compared before and after lavage between two groups.ResultsThere were no significant difference in age, gender, GCS score, APPACHE Ⅱ score and CRP before lavation in both groups(P>0.05), and there was also no  statistical difference in lavage number, average duration of lavage, and aspirated sputum volume between two groups (P=0.05); mucosolvan group had less time on the ventilator ( ［63.57±21.94］h )and less  day to stay in ICU(［6.24±1.04］d) than saline group（［88.24±21.35］h, ［7.95±1.36］d ,respectively）(t=-3.69,P=0.00;t=-4.58,P=0.00) ; at the 3rd  and 4th day after lavage ,  CPIS in mucosolvan group was (2.36±0.77) and ( 2.17±0.81) respectively, which were significantly lower than saline group(［4.16±0.86］,［3.54±1.09］, respectively)(t=3.60,P=0.00;t=2.25,P=0.03).ConclusionMucosolvan bronchoalveolar lavage can promote stroke patients to  recover from pulmonary  infection.