Abstract:ObjectiveTo investigate the state and risk factors for nosocomial infection (NI) in a general intensive care unit(ICU) .MethodsPatients who were hospitalized in ICU for >48 hours between JanuaryDecember, 2007 were investigated by targeted monitor methods.ResultsA total of 214 patients were surveyed, 51 patients developed 67 cases of NI, NI rate was 23.83%, NI case rate was 31.31%. The main infection sites were lung (71.64%) and urinary tract (11.94%). 217 strains of pathogens were isolated, 116(53.46%) of which were gramnegative bacilli, 82(37.79%) were grampositive cocci, 19(8.76%) were fungi. The top 4 pathogens were Staphylococcus aureus (26.73%), Acinetobacter baumannii(10.06%), Enterococci spp.(10.60%), and Pseudomonas aeruginosa(9.68%). The risk factors for NI were age≥58 years old, dysfunctin of organs, use of respirator, long length of staying in ICU.ConclusionNI is high in ICU patients, the major pathogen is gramnegative bacilli, prevention should be carried out according to the related risk factors and commonly occurred NI.