湖南省细菌耐药监测网2012—2021年肠球菌属细菌耐药性监测报告

Antimicrobial resistance of Enterococcus spp.: surveillance report from Hunan Province Antimicrobial Resistance Surveillance System, 2012-2021

摘要:

目的 了解湖南省临床分离肠球菌属细菌对各类抗菌药物的耐药情况及变迁。方法 收集湖南省细菌耐药监测网成员单位2012—2021年临床分离的肠球菌属细菌耐药性监测数据,按照统一方法进行数据清洗后应用WHONET 5.6软件进行统计分析。结果 2012—2021年共纳入110 652株非重复肠球菌属细菌,主要为粪肠球菌、屎肠球菌,分别占46.9%(37 774株)、45.9%(36 968株),其次为鸟肠球菌(2.5%,1 982株)、鹑鸡肠球菌(1.8%,1 428株)、铅黄肠球菌(1.5%,1 185株)。肠球菌属细菌主要标本来源为尿(51.8%,57 350株),其次是分泌物(9.6%,10 660株)、胆汁(8.5%,9 377株)。2012—2021年粪肠球菌对氨苄西林、替考拉宁和万古霉素的耐药率分别为5.5%~12.0%、1.3%~2.0%、0.6%~1.4%,屎肠球菌对氨苄西林、替考拉宁和万古霉素的耐药率分别为69.2%~85.0%、1.5%~2.8%、0.7%~2.5%。除利奈唑胺和米诺环素,屎肠球菌对检测抗菌药物的耐药率均高于粪肠球菌。粪肠球菌、屎肠球菌对万古霉素的耐药率分别从2012年的1.4%、2.1%下降至2021年的0.6%、0.7%,呈下降趋势。结论 肠球菌属临床分离菌对万古霉素和替考拉宁保持较好的敏感性,粪肠球菌、屎肠球菌对万古霉素的耐药率呈下降趋势。

关键词:肠球菌属;细菌耐药性监测;耐药性变迁;抗菌药物;湖南省细菌耐药监测网

Abstract:

Objective To understand the antimicrobial resistance of clinically isolated Enterococcus spp. in Hunan Province. Methods Surveillance data of Enterococcus spp. resistance from member units of Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021 were collected. Data were cleaned according to a unified method, and WHONET 5.6 software was adopted for statistical analysis. Results From 2012 to 2021, a total of 110 652 non-repetitive Enterococcus spp. strains were included in the analysis, mainly Enterococcus faecalis and Enterococcus faecium, accounting for 46.9% (n=37 774) and 45.9% (n=36 968), respectively, followed by Enterococcus avium (2.5%, n=1 982), Enterococcus gallinarum (1.8%, n=1 428), and Enterococcus casseliflavus (1.5%, n=1 185). The main specimen sources of Enterococcus spp. was urine (51.8%, n=57 350), followed by secretions (9.6%, n=10 660) and bile (8.5%, n=9 377). From 2012 to 2021, the resistance rates of Enteroco-ccus faecalis to ampicillin, teicoplanin, and vancomycin were 5.5%-12.0%, 1.3%-2.0%, and 0.6%-1.4%, respectively. The resistance rates of Enterococcus faecium to ampicillin, teicoplanin, and vancomycin were 69.2%-85.0%, 1.5%-2.8%, and 0.7%-2.5%, respectively. Except for linezolid and minocycline, the resistance rates of Enterococcus faecium to tested antimicrobial agents were all higher than those of Enterococcus faecalis. The resistance rates of Enterococcus faecalis and Enterococcus faecium to vancomycin decreased from 1.4% and 2.1% in 2012 to 0.6% and 0.7% in 2021, respectively, presenting a decreased trend. Conclusion Clinically isolated Enterococcus spp. maintain high antimicrobial susceptibility to vancomycin and teicoplanin. Resistance rates of Enterococcus faecalis and Enterococcus faecium to vancomycin present decreased trends.

Key words:Enterococcus spp.;bacterial resistance surveillance;change in antimicrobial resistance;antimicrobial agent;Hunan Provincial Antimicrobial Resistance Surveillance System