SARS-CoV-2 S蛋白引起呼吸道上皮细胞炎症反应的研究进展

Advances in SARS-CoV-2 S protein-induced inflammatory response of respiratory epithelial cells

摘要:

严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)感染引起的肺炎对人类生命健康产生威胁, 对社会经济造成巨大损失。病毒的结构蛋白刺突蛋白(S蛋白)一直被认为主要介导病毒侵入宿主细胞。S蛋白可独立于病毒引起多种细胞产生炎症反应, 因此, 了解S蛋白本身对呼吸道的影响能够为防治新型冠状病毒感染提供新视角。本文对SARS-CoV-2结构蛋白S蛋白引起呼吸道上皮细胞炎症反应的可能机制、临床表现等方面的研究进展进行了梳理, 以期为疾病的预防和治疗提供参考。

Abstract:

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection poses a threat to human life and health, resulting in great socio-economic losses. The structural protein spike protein (S protein) of viruses has always been considered to primarily mediate virus invasion into host cells. S protein can act independently of viruses and cause inflammatory reactions on a variety of cells, therefore, understanding the impact of S protein on the respiratory tract can provide a new perspective for the prevention and treatment of COVID -19. This article reviews the advances in the possible mechanisms and clinical manifestations of SARS-CoV-2 structural protein S protein-induced inflammatory response in respiratory epithelial cells, aiming to provide reference for the prevention and treatment of diseases.